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Article

Identification of AP80978, a novel small-molecule inhibitor of hepatitis C virus replication that targets NS4B.

Antimicrobial agents and chemotherapy - 1 Jun 2014

Dufner-Beattie Jodi, O'Guin Andrew, O'Guin Stephanie, Briley Aaron, Wang Bin, Balsarotti Jennifer, Roth Robert, Starkey Gale, Slomczynska Urszula, Noueiry Amine, Olivo Paul D, Rice Charles M

Abstract excerpt

A small-molecule inhibitor of hepatitis C virus (HCV) designated AP89652 was identified by screening a compound library with an HCV genotype 1b subgenomic replicon assay. AP89652 contains two chiral centers, and testing of two syn enantiomers revealed that activity in the replicon assay resided with only one, AP80978, whose 50% effective concentration (EC50) (the concentration at which a 50% reduction in Renilla...

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Identifiers

PMID: 24709254
DOI: 10.1128/AAC.00113-14
PMCID: PMC4068439

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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