Article
[Pseudogene PTENP1 5'-region methylation in endometrial cancer and hyperplasias].
Bioorganicheskaia khimiia - 1 Jan 2000
Kovalenko T F, Sorokina A V, Ozolinia L A, Patrushev L I
Abstract excerpt
Genetic mutations in tumor suppressor gene PTEN are often detected in malignant human cells and these genomic changes are especially characteristic ofendometrial cancer. In our previous researches we assumed that alternative epigenetic mechanism of PTEN inactivation trough promoter methylation may exist in endometrial cancer. Moreover, PTENP1 pseudogene has recently been shown to play a role in positive...
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