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Article

Long-term weight-loss in gastric bypass patients carrying melanocortin 4 receptor variants.

PloS one - 1 Jan 2014

Moore Bryn S, Mirshahi Uyenlinh L, Yost Evan A, Stepanchick Ann N, Bedrin Michael D, Styer Amanda M, Jackson Kathryn K, Still Christopher D, Breitwieser Gerda E, Gerhard Glenn S, Carey David J, Mirshahi Tooraj

Abstract excerpt

BACKGROUND: The melanocortin 4 receptor (MC4R) critically regulates feeding and satiety. Rare variants in MC4R are predominantly found in obese individuals. Though some rare variants in MC4R discovered in patients have defects in localization, ligand binding and signaling to cAMP, many have no recognized defects. SUBJECTS/METHODS: In our cohort of 1433 obese subjects that underwent Roux-en-Y Gastric Bypass (RYGB)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24705671
DOI: 10.1371/journal.pone.0093629
PMCID: PMC3976318

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