Article
Competitive fitness in coronaviruses is not correlated with size or number of double-membrane vesicles under reduced-temperature growth conditions.
mBio - 1 Apr 2014
Al-Mulla Hawaa M N, Turrell Lauren, Smith Nicola M, Payne Luke, Baliji Surendranath, Züst Roland, Thiel Volker, Baker Susan C, Siddell Stuart G, Neuman Benjamin W
Abstract excerpt
Positive-stranded viruses synthesize their RNA in membrane-bound organelles, but it is not clear how this benefits the virus or the host. For coronaviruses, these organelles take the form of double-membrane vesicles (DMVs) interconnected by a convoluted membrane network. We used electron microscopy to identify murine coronaviruses with mutations in nsp3 and nsp14 that replicated normally while producing only half...
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