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Mutations across Murine Hepatitis Virus nsp4 Alter Virus Fitness and Membrane Modifications

4 Dec 2014

Abstract excerpt

UNLABELLED: A common feature of infection by positive-sense RNA virus is the modification of host cell cytoplasmic membranes that serve as sites of viral RNA synthesis. Coronaviruses induce double-membrane vesicles (DMVs), but the role of DMVs in replication and virus fitness remains unclear. Coronaviruses encode 16 nonstructural proteins (nsps), three of which, nsp3, nsp4, and nsp6, are necessary and sufficient...

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PMID: 25473044
DOI: 10.1128/jvi.02776-14

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