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Article

Depletion of cutaneous macrophages and dendritic cells promotes growth of basal cell carcinoma in mice.

PloS one - 1 Jan 2014

König Simone, Nitzki Frauke, Uhmann Anja, Dittmann Kai, Theiss-Suennemann Jennifer, Herrmann Markus, Reichardt Holger M, Schwendener Reto, Pukrop Tobias, Schulz-Schaeffer Walter, Hahn Heidi

Abstract excerpt

Basal cell carcinoma (BCC) belongs to the group of non-melanoma skin tumors and is the most common tumor in the western world. BCC arises due to mutations in the tumor suppressor gene Patched1 (Ptch). Analysis of the conditional Ptch knockout mouse model for BCC reveals that macrophages and dendritic cells (DC) of the skin play an important role in BCC growth restraining processes. This is based on the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24691432
DOI: 10.1371/journal.pone.0093555
PMCID: PMC3972151

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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