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Article

Topical tazarotene chemoprevention reduces Basal cell carcinoma number and size in Ptch1+/- mice exposed to ultraviolet or ionizing radiation.

Cancer research - 1 Jul 2004

So Po-Lin, Lee Kenneth, Hebert Jennifer, Walker Patricia, Lu Ying, Hwang Jimmy, Kopelovich Levy, Athar Mohammed, Bickers David, Aszterbaum Michelle, Epstein Ervin H

Abstract excerpt

Oral retinoids can reduce basal cell carcinoma (BCC) incidence in genetically susceptible patients, and one topical retinoid, tazarotene, has been reported to cure some sporadic BCCs. Therefore, we have tested whether this agent would affect BCCs in Ptch1+/- mice in a controlled chemoprevention trial. We found that topical tazarotene dramatically inhibits the formation of BCCs induced with either UV or ionizing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Basal Cell

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Source

Identifiers

PMID: 15231643
DOI: 10.1158/0008-5472.CAN-03-1927

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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