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Article

Genotype-environment interaction: apolipoprotein E (ApoE) gene effects and age as an index of time and spatial context in the human.

Genetics - 1 May 1996

Zerba K E, Ferrell R E, Sing C F

Abstract excerpt

We analyzed the age-dependence of the estimates of the parameters of the genetic architecture of plasma ApoE levels associated with ApoE gene variation. Our study sample included 1988 individuals in multigeneration pedigrees from the Rochester, MN, population. We used a 30-yr sliding window across the age range (5-90 yr) to estimate the age dependency of parameters. Additive ApoE allelic variance of transformed...

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Identifiers

PMID: 8722796
DOI: 10.1093/genetics/143.1.463
PMCID: PMC1207278

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