Genotype-environment interaction: apolipoprotein E (ApoE) gene effects and age as an index of time and spatial context in the human.

doi:10.1093/genetics/143.1.463

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Article

Genotype-environment interaction: apolipoprotein E (ApoE) gene effects and age as an index of time and spatial context in the human.

Genetics - 1 May 1996

Zerba K E, Ferrell R E, Sing C F

Abstract excerpt

We analyzed the age-dependence of the estimates of the parameters of the genetic architecture of plasma ApoE levels associated with ApoE gene variation. Our study sample included 1988 individuals in multigeneration pedigrees from the Rochester, MN, population. We used a 30-yr sliding window acros...

Topics

Adolescent
Adult
Aged
Aged, 80 and over
Aging
Apolipoproteins E
Child
Child, Preschool
Environment
Female
Genetic Variation
Genotype
Humans
Male
Middle Aged
Phenotype
Regression Analysis
Sex Characteristics

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