Article

Long-chain polyphosphates induce glomerular microthrombi and exacerbate LPS-induced acute kidney injury in mouse

2025-07-18

Abstract excerpt

Polyphosphates are evolutionarily conserved anionic polymers mediating pleiotropic functions in eukaryotes and prokaryotes, depending on their chain-length. Bacteria typically synthetize long-chains, while human platelets harbour exclusively medium-chains. Polyphosphate-mediated lung and liver-injury have been reported in experimental mouse models but their effects on the kidney remain undefined. Here we assessed...

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Literature Corpus work: eff1aa54-f5a4-55c2-b475-90a7708e35b7
DOI: 10.1101/2025.07.17.664574

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