Article
Reactive Oxygen Species-Mediated TRPM2 Activation Facilitates Phagocytosis of Macrophages to Reverse Profibrotic Phenotype.
Liver international : official journal of the International Association for the Study of the Liver - 1 Oct 2025
Zhang Shaoying, Liang Fanfan, Wan Dan, Zhang Chongyu, Zhang Yinggang, Zhang Xurui, Huang Na, Feng Keping, Liang Xiao, Guo Ni, Zhang Chen, Zhou Zhe, Li Yuehua, Geng Jing, Liu Pengfei, Kong Guangyao, Lu Shemin, Li Zongfang
Abstract excerpt
BACKGROUND AND AIMS: Macrophages play plastic roles during fibrogenesis and fibrosis regression. Phagocytosis is considered a trigger for shifting macrophages from a profibrotic phenotype to a restorative phenotype. However, the underlying mechanism by which macrophages enhance phagocytosis remains unclear. Our present study investigated the role of reactive oxygen species (ROS)-modulated TRPM2 activation in this...
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