Article
Fusidic acid-resistant EF-G perturbs the accumulation of ppGpp.
Molecular microbiology - 1 Jul 2000
Macvanin M, Johanson U, Ehrenberg M, Hughes D
Abstract excerpt
Reductions in growth rate caused by fusidic acid-resistant EF-G mutants in Salmonella typhimurium correlate strongly with increased mean cell size. This is unusual because growth rate and cell size normally correlate positively. The global transcription regulator molecule ppGpp has a role in co-ordinating growth rate and division, and its basal level normally correlates inversely with cell size at division. We...
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