Fusidic acid-resistant EF-G perturbs the accumulation of ppGpp.

doi:10.1046/j.1365-2958.2000.01967.x

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Article

Fusidic acid-resistant EF-G perturbs the accumulation of ppGpp.

Molecular microbiology - 1 Jul 2000

Macvanin M, Johanson U, Ehrenberg M, Hughes D

Abstract excerpt

Reductions in growth rate caused by fusidic acid-resistant EF-G mutants in Salmonella typhimurium correlate strongly with increased mean cell size. This is unusual because growth rate and cell size normally correlate positively. The global transcription regulator molecule ppGpp has a role in co-ordinating growth rate and division, and its basal level normally correlates inversely with cell size at division. We...

Topics

Anti-Bacterial Agents
Drug Resistance, Microbial
Fusidic Acid
Guanosine Tetraphosphate
Mutation
Peptide Elongation Factor G
Protein Biosynthesis
Salmonella typhimurium

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Open in PubMed

Identifiers

PMID: 10931308
DOI: 10.1046/j.1365-2958.2000.01967.x

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