Identification of CHRNA5 rare variants in African-American heavy smokers.

doi:10.1097/YPG.0000000000000029

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Article

Identification of CHRNA5 rare variants in African-American heavy smokers.

Psychiatric genetics - 1 Jun 2014

Doyle Glenn A, Chou Andrew D, Saung Wint Thu, Lai Alison T, Lohoff Falk W, Berrettini Wade H

Abstract excerpt

BACKGROUND: The common CHRNA5 mis-sense coding single-nucleotide polymorphism (SNP) rs16969968:G>A (D398N) has repeatedly been shown to confer risk for heavy smoking in individuals who carry the 'A' allele (encoding the 398N amino acid). The mis-sense SNP has a minor allele frequency of ∼40% in European-Americans, but only ∼7% in African-Americans (http://www.ncbi.nlm.nih.gov/projects/SNP/). We reasoned that...

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Identifiers

PMID: 24682045
DOI: 10.1097/YPG.0000000000000029
PMCID: PMC4015337

Genes

CHRNA5

Variants

rs16969968

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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