DNA methylation of serotonin genes as predictive biomarkers of antidepressant treatment response

doi:10.1016/j.pnpbp.2024.111160

Article

DNA methylation of serotonin genes as predictive biomarkers of antidepressant treatment response

3 Oct 2024

Abstract excerpt

Selective serotonin reuptake inhibitors (SSRI) are frequently ineffective in treating depressive episodes and biomarkers are needed to optimize antidepressant treatment outcomes. DNA methylation levels of serotonin transporter ( SLC6A4 ) and tryptophan hydroxylase 2 genes ( TPH2 ) have been suggested to predict antidepressant clinical outcomes but their applicability remains uncertain. In this study, we: 1)...

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.