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Article

Whole Blood Thromboelastometry by ROTEM and Thrombin Generation by Genesia According to the Genotype and Clinical Phenotype in Congenital Fibrinogen Disorders.

International journal of molecular sciences - 25 Feb 2021

Szanto Timea, Lassila Riitta, Lemponen Marja, Lehtinen Elina, Neerman-Arbez Marguerite, Casini Alessandro

Abstract excerpt

The outcome of congenital fibrinogen defects (CFD) is often unpredictable. Standard coagulation assays fail to predict the clinical phenotype. We aimed to assess the pheno- and genotypic associations of thrombin generation (TG) and ROTEM in CFD. We measured fibrinogen (Fg) activity and antigen, prothrombin fragments F1+2, and TG by ST Genesia® with both Bleed- and ThromboScreen in 22 patients. ROTEM was available...

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Identifiers

PMID: 33668986
DOI: 10.3390/ijms22052286
PMCID: PMC7956597

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