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Functional and structural consequences of fibrinogen γ-chain variants associated with thrombotic phenotype in congenital fibrinogen disorders.

Thrombosis research - 1 Apr 2026

Simurda Tomas, Ceznerova Eliska, Kolkova Zuzana, Loderer Dusan, Drotarova Miroslava, Brunclikova Monika, Skornova Ingrid, Agouba Sohaib Mukhtar, Gemelova Veronika Voskova, Belakova Kristina Maria, Stasko Jan, Kotlin Roman

Abstract excerpt

Fibrinogen is a key determinant of clot formation and stability in the final phase of coagulation. Genetic variants in the fibrinogen γ-chain gene (FGG) are a frequent cause of congenital fibrinogen disorders (CFDs) and are associated with marked heterogeneity of clinical presentation, including thrombosis. Increasing evidence indicates that genetic findings alone are insufficient to predict thrombotic risk. We...

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PMID: 41926907
DOI: 10.1016/j.thromres.2026.109664

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FGG

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