Article
An exploratory plasma-based functional assay for phenotypic characterization of fibrinolysis in dysfibrinogenemia.
Research and practice in thrombosis and haemostasis - 1 Mar 2026
Suzuki Atsuo, Okamoto Shuichi, Suzuki Nobuaki, Tamura Shogo, Kanematsu Takeshi, Tomita Masashi, Kojima Tetsuhito, Matsushita Tadashi
Abstract excerpt
Background: Congenital dysfibrinogenemia exhibits heterogeneous clinical phenotypes, ranging from bleeding to thrombosis. However, conventional fibrinogen assays primarily evaluate clot formation alone. Genetic analyses are informative but do not fully explain phenotypic diversity, particularly with respect to clot formation-lysis behavior. Objectives: This study developed a novel plasma-based functional assay...
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