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Article

Roles of JAK2 in Aging, Inflammation, Hematopoiesis and Malignant Transformation

8 Aug 2019

Abstract excerpt

Clonal alterations in hematopoietic cells occur during aging and are often associated with the establishment of a subclinical inflammatory environment. Several age-related conditions and diseases may be initiated or promoted by these alterations. JAK2 mutations are among the most frequently mutated genes in blood cells during aging. The most common mutation within the JAK2 gene is JAK2-V617F that leads to...

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PMID: 31398915
DOI: 10.3390/cells8080854

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