Regional and developmental expression of the Npc1 mRNA in the mouse brain.

Abstract excerpt

Niemann-Pick type C (NP-C) disease is a fatal, autosomal recessive disorder of cholesterol metabolism that results in progressive central nervous system deterioration and premature death. Recently, a gene mutated in NP-C disease (NPC1) was identified in both human patients and in the npc(nih) mouse model. Although the function of the NPC1 gene is at present unknown, determining the pattern of its expression in...

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