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Article

Genetic Susceptibility to Autism Spectrum Disorders: Folate Pathway Polymorphisms, Mediterranean Diet and Evolutionary Insights.

Journal of molecular neuroscience : MN - 29 May 2026

Bonifacio Maria Addolorata, Vinella Angela, Pafundi Mariella, Margari Lucia, Mariggiò Maria Addolorata

Abstract excerpt

Autism spectrum disorders (ASD) represent a complex medical and social issue with a multifactorial etiology, often correlated with the host genetic background, particularly with the folate metabolic pathway. This study aimed to investigate the association between MTHFR (C677T and A1298C) and MTRR (A66G) polymorphisms and ASD susceptibility in an Apulian cohort. We analyzed 73 patients diagnosed with ASD and 84...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42213268
DOI: 10.1007/s12031-026-02552-7

Genes

MTHFR
MTRR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Genetic Susceptibility to Autism Spectrum Disorders: Folate Pathway Polymorphisms, Mediterranean Diet and Evolutionary Insights.PMID 42213268Read ↗

Association between MTHFR gene polymorphisms and the risk of autism spectrum disorders: a meta-analysis.Semantic proximity Read ↗

Study of the C677T and 1298AC polymorphic genotypes of MTHFR Gene in autism spectrum disorderSemantic proximity Read ↗

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Genetics and Epigenetics of One-Carbon Metabolism Pathway in Autism Spectrum Disorder: A Sex-Specific Brain Epigenome?Semantic proximity Read ↗

Association of methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism with autism: evidence of genetic susceptibility.Semantic proximity Read ↗

<i>MTHFR</i> Gene C677T Polymorphism in Autism Spectrum DisordersSemantic proximity Read ↗

Clinical utility of folate pathway genetic polymorphisms in the diagnosis of autism spectrum disorders.Semantic proximity Read ↗

Evaluation of C677T Polymorphism of the Methylenetetrahydrofolate Reductase (MTHFR) Gene in various Neurological DisordersSemantic proximity Read ↗

The MTHFR 677C-->T polymorphism and behaviors in children with autism: exploratory genotype-phenotype correlations.Semantic proximity Read ↗

Aberrations in folate metabolic pathway and altered susceptibility to autism.Semantic proximity Read ↗

MTHFR Gene Polymorphisms: A Single Gene with Wide-Ranging Clinical Implications—A ReviewSemantic proximity Read ↗

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