Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RIP140 increases APC expression and controls intestinal homeostasis and tumorigenesis

25 Mar 2014

Abstract excerpt

Deregulation of the Wnt/APC/β-catenin signaling pathway is an important consequence of tumor suppressor APC dysfunction. Genetic and molecular data have established that disruption of this pathway contributes to the development of colorectal cancer. Here, we demonstrate that the transcriptional coregulator RIP140 regulates intestinal homeostasis and tumorigenesis. Using Rip140-null mice and mice overexpressing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related gene regulation
Share to Genetic factors in colorectal cancer
Share to Wnt/β-catenin signaling in development and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24667635
DOI: 10.1172/jci65178

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RIP140 increases APC expression and controls intestinal homeostasis and tumorigenesisPMID 24667635Read ↗

RIP140 regulates HES1 oscillatory expression and mitogenic activity in colon cancer cellsSemantic proximity Read ↗

RIP140 Represses Intestinal Paneth Cell Differentiation and Interplays with SOX9 Signaling in Colorectal CancerSemantic proximity Read ↗

Pin1 inhibition potently suppresses gastric cancer growth and blocks PI3K/AKT and Wnt/β‐catenin oncogenic pathwaysSemantic proximity Read ↗

DPEP1, expressed in the early stages of colon carcinogenesis, affects cancer cell invasiveness.Semantic proximity Read ↗

IPO11 mediates βcatenin nuclear import in a subset of colorectal cancers.Semantic proximity Read ↗

A <i>Ctnnb1</i> enhancer transcriptionally regulates Wnt signaling dosage to balance homeostasis and tumorigenesis of intestinal epitheliaSemantic proximity Read ↗

Pleiotropic Effects of PPARD Accelerate Colorectal Tumorigenesis, Progression, and InvasionSemantic proximity Read ↗

Suppression of intestinal carcinogenesis in Apc-mutant mice by limoninSemantic proximity Read ↗

Targeting phospholipase D1 attenuates intestinal tumorigenesis by controlling β-catenin signaling in cancer-initiating cellsSemantic proximity Read ↗

Evaluation of Rint1 as a modifier of intestinal tumorigenesis and cancer risk.Semantic proximity Read ↗

NHERF1/EBP50 Suppresses Wnt-β-Catenin Pathway-Driven Intestinal Neoplasia.Semantic proximity Read ↗

The role of Pygo2 for Wnt/ß-catenin signaling activity during intestinal tumor initiation and progression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.