Article

RIP140 regulates HES1 oscillatory expression and mitogenic activity in colon cancer cells

2023-05-14

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> The transcription factor RIP140 (Receptor Interacting Protein of 140 kDa) regulates intestinal homeostasis and tumorigenesis through the Wnt signaling. In this study, we have investigated its effect on the Notch/HES1 signaling pathway. <h4>Methods</h4> The impact on HES1 expression and activity was evaluated in colorectal cancer (CRC) cell lines and in transgenic mice, inva...

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Literature Corpus work: f83aa8fa-e315-59ec-acd0-6e446b31c549
DOI: 10.1101/2023.05.13.539637

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