Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evaluation of Rint1 as a modifier of intestinal tumorigenesis and cancer risk.

PloS one - 1 Jan 2017

Otterpohl Karla L, Gould Karen A

Abstract excerpt

The Rad50 Interacting Protein 1 (Rint1) influences cellular homeostasis through maintenance of endoplasmic reticulum, Golgi and centrosome integrity and regulation of vesicle transport, autophagy and the G2/M checkpoint. Rint1 has been postulated to function as a tumor suppressor as well as an oncogene, with its role depending perhaps upon the precise cellular and/or experimental context. In humans,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Transformation, Neoplastic
Share to Colorectal Neoplasms
Share to Genes, Lethal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Background

Share to Intestinal Mucosa

Share to Tumor Burden

Share to Tumor Suppressor Proteins

Share to Vesicular Transport Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 28264000
DOI: 10.1371/journal.pone.0172247
PMCID: PMC5339343

Genes

RINT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evaluation of Rint1 as a modifier of intestinal tumorigenesis and cancer risk.PMID 28264000Read ↗

Rare mutations in RINT1 predispose carriers to breast and Lynch syndrome-spectrum cancers.Semantic proximity Read ↗

Reevaluation of RINT1 as a breast cancer predisposition gene.Semantic proximity Read ↗

p53 protein degradation redefines the initiation mechanisms and drives transitional mutations in colorectal cancerSemantic proximity Read ↗

A Rare Variant P507L in TPP1 Interrupts TPP1–TIN2 Interaction, Influences Telomere Length, and Confers Colorectal Cancer Risk in Chinese PopulationSemantic proximity Read ↗

NIAM-deficient mice are predisposed to the development of proliferative lesions including B-cell lymphomas.Semantic proximity Read ↗

Monoallelic NTHL1 Loss-of-Function Variants and Risk of Polyposis and Colorectal Cancer.Semantic proximity Read ↗

Characterization of an intelectin-1 (Itln1) knockout mouse modelSemantic proximity Read ↗

Genetic evaluation of candidate genes for the Mom1 modifier of intestinal neoplasia in mice.Semantic proximity Read ↗

Rap1 and its effector KRIT1/CCM1 regulate β-catenin signalingSemantic proximity Read ↗

Contrasting effects of Deadend1 (Dnd1) gain and loss of function mutations on allelic inheritance, testicular cancer, and intestinal polyposis.Semantic proximity Read ↗

Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancersSemantic proximity Read ↗

T851I mutation of human large tumor suppressor 1 disrupts its kinase activity and tumor-suppressor functions.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.