Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Endoplasmic reticulum stress is accompanied by activation of NF-κB in amyotrophic lateral sclerosis.

Journal of neuroimmunology - 15 May 2014

Prell T, Lautenschläger J, Weidemann L, Ruhmer J, Witte O W, Grosskreutz J

Abstract excerpt

BACKGROUND: Recent studies have indicated that endoplasmic reticulum (ER) stress is involved in the pathogenesis of amyotrophic lateral sclerosis (ALS). ER stress occurs when the ER-mitochondria calcium cycle is disturbed and misfolded proteins accumulate in the ER. To cope with ER stress, cells activate the unfolded protein response (UPR). Accumulating evidence from non-neuronal cell models suggests that there...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis
Share to Blotting, Western

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endoplasmic Reticulum Stress

Share to Motor Neurons

Share to NF-kappa B

Share to Superoxide Dismutase

Share to Superoxide Dismutase-1

Share to Unfolded Protein Response

Source

Identifiers

PMID: 24666819
DOI: 10.1016/j.jneuroim.2014.03.005

Genes

SOD1
ATF6
XBP1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Endoplasmic reticulum stress is accompanied by activation of NF-κB in amyotrophic lateral sclerosis.PMID 24666819Read ↗

Endoplasmic reticulum stress plays an important role in amyotrophic lateral sclerosis (commentary on Prell et al.).Semantic proximity Read ↗

Stress signaling from the endoplasmic reticulum: A central player in the pathogenesis of amyotrophic lateral sclerosisSemantic proximity Read ↗

The unfolded protein response in models of human mutant G93A amyotrophic lateral sclerosis.Semantic proximity Read ↗

ER Stress and UPR in Familial Amyotrophic Lateral SclerosisSemantic proximity Read ↗

Is Innate Immunity and Inflammasomes Involved in Pathogenesis of Amyotrophic Lateral Sclerosis (ALS)?Semantic proximity Read ↗

Amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease (AD) are characterised by differential activation of ER stress pathways: focus on UPR target genesSemantic proximity Read ↗

The Links between ALS and NF-κB.Semantic proximity Read ↗

NLRP3 Inflammasome Activation in a Transgenic Amyotrophic Lateral Sclerosis Model.Semantic proximity Read ↗

XBP-1 deficiency in the nervous system reveals a homeostatic switch to activate autophagySemantic proximity Read ↗

Preliminary exploration of endoplasmic reticulum stress transmission in astrocytes and neurons, and its mediatorsSemantic proximity Read ↗

Activation of interferon signaling pathways in spinal cord astrocytes from an ALS mouse modelSemantic proximity Read ↗

Functional Contribution of the Transcription Factor ATF4 to the Pathogenesis of Amyotrophic Lateral SclerosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.