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Article

The unfolded protein response in models of human mutant G93A amyotrophic lateral sclerosis.

The European journal of neuroscience - 1 Mar 2012

Prell T, Lautenschläger J, Witte O W, Carri M T, Grosskreutz J

Abstract excerpt

Recent studies indicate that endoplasmic reticulum (ER) stress is involved in the pathogenesis of familial and sporadic amyotrophic lateral sclerosis (ALS). ER stress occurs when the ER-mitochondria calcium cycle (ERMCC) is disturbed and misfolded proteins accumulate in the ER. To cope with ER stress, the cell engages the unfolded protein response (UPR). While activation of the UPR has been shown in some ALS...

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Source

Identifiers

PMID: 22390177
DOI: 10.1111/j.1460-9568.2012.08008.x

Genes

SOD1
XBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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