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Article

The unfolded protein response in models of human mutant G93A amyotrophic lateral sclerosis.

The European journal of neuroscience - 1 Mar 2012

Prell T, Lautenschläger J, Witte O W, Carri M T, Grosskreutz J

Abstract excerpt

Recent studies indicate that endoplasmic reticulum (ER) stress is involved in the pathogenesis of familial and sporadic amyotrophic lateral sclerosis (ALS). ER stress occurs when the ER-mitochondria calcium cycle (ERMCC) is disturbed and misfolded proteins accumulate in the ER. To cope with ER st...

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Source

Identifiers

PMID: 22390177
DOI: 10.1111/j.1460-9568.2012.08008.x

Genes

SOD1
XBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22390177-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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