Article

Disrupted choline clearance and sustained acetylcholine release <i>in vivo</i> by a common choline transporter coding variant associated with poor attentional control in humans

2021-06-28

Abstract excerpt

Transport of choline via the neuronal high-affinity choline transporter (CHT; SLC5A7) is essential for cholinergic terminals to synthesize and release acetylcholine (ACh). In humans, we previously demonstrated an association between a common CHT coding substitution (rs1013940; Ile89Val) and reduced attentional control as well as attenuated frontal cortex activation. Here, we used a CRISPR/Cas9 approach to generat...

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Literature Corpus work: e5902d35-74a0-5547-8a2b-571b6c4d5329
DOI: 10.1101/2021.06.27.450076

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Disrupted choline clearance and sustained acetylcholine release <i>in vivo</i> by a common choline transporter coding variant associated with poor attentional control in humansDOI 10.1101/2021.06.27.450076Read

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