Article
Contribution of higher risk genes and European admixture to Crohn's disease in African Americans.
Inflammatory bowel diseases - 1 Dec 2012
Wang Ming-Hsi, Okazaki Toshihiko, Kugathasan Subra, Cho Judy H, Isaacs Kim L, Lewis James D, Smoot Duane T, Valentine John F, Kader Howard A, Ford Jean G, Harris Mary L, Oliva-Hemker Maria, Cuffari Carmen, Torbenson Michael S, Duerr Richard H, Silverberg Mark S, Rioux John D, Taylor Kent D, Nguyen Geoffrey C, Wu Yuqiong, Datta Lisa W, Hooker Stanley, Dassopoulos Themistocles, Kittles Rick A, Kao Linda W H, Brant Steven R
Abstract excerpt
BACKGROUND: African Americans (AAs) are an admixed population of West African (WA) and European ancestry (EA). Crohn's disease (CD) susceptibility genes have not been established. We therefore evaluated the contribution of European admixture and major established risk genes to AA CD. METHODS: Ninety-seven admixture informative markers were genotyped for ancestry estimates using STRUCTURE. Overall, 354 AA CD cases...
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