Article
Laboratory detection of artemisinin-resistant Plasmodium falciparum.
Antimicrobial agents and chemotherapy - 1 Jun 2014
Chotivanich Kesinee, Tripura Rupam, Das Debashish, Yi Poravuth, Day Nicholas P J, Pukrittayakamee Sasithon, Chuor Char Meng, Socheat Duong, Dondorp Arjen M, White Nicholas J
Abstract excerpt
Conventional 48-h in vitro susceptibility tests have low sensitivity in identifying artemisinin-resistant Plasmodium falciparum, defined phenotypically by low in vivo parasite clearance rates. We hypothesized originally that this discrepancy was explained by a loss of ring-stage susceptibility and so developed a simple field-adapted 24-h trophozoite maturation inhibition (TMI) assay focusing on the ring stage and...
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