Article
Artemisinin-resistant Plasmodium falciparum in Pursat province, western Cambodia: a parasite clearance rate study.
The Lancet. Infectious diseases - 1 Nov 2012
Amaratunga Chanaki, Sreng Sokunthea, Suon Seila, Phelps Erika S, Stepniewska Kasia, Lim Pharath, Zhou Chongjun, Mao Sivanna, Anderson Jennifer M, Lindegardh Niklas, Jiang Hongying, Song Jianping, Su Xin-zhuan, White Nicholas J, Dondorp Arjen M, Anderson Tim J C, Fay Michael P, Mu Jianbing, Duong Socheat, Fairhurst Rick M
Abstract excerpt
BACKGROUND: Artemisinin-resistant Plasmodium falciparum has been reported in Pailin, western Cambodia, detected as a slow parasite clearance rate in vivo. Emergence of this phenotype in western Thailand and possibly elsewhere threatens to compromise the effectiveness of all artemisinin-based combination therapies. Parasite genetics is associated with parasite clearance rate but does not account for all variation....
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