Article
Plasmodium falciparum founder populations in western Cambodia have reduced artemisinin sensitivity in vitro.
Antimicrobial agents and chemotherapy - 1 Aug 2014
Amaratunga Chanaki, Witkowski Benoit, Dek Dalin, Try Vorleak, Khim Nimol, Miotto Olivo, Ménard Didier, Fairhurst Rick M
Abstract excerpt
Reduced Plasmodium falciparum sensitivity to short-course artemisinin (ART) monotherapy manifests as a long parasite clearance half-life. We recently defined three parasite founder populations with long half-lives in Pursat, western Cambodia, where reduced ART sensitivity is prevalent. Using the ring-stage survival assay, we show that these founder populations have reduced ART sensitivity in vitro at the early...
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