Article
Artemisinin-resistant Plasmodium falciparum parasites exhibit altered patterns of development in infected erythrocytes.
Antimicrobial agents and chemotherapy - 1 Jan 2015
Hott Amanda, Casandra Debora, Sparks Kansas N, Morton Lindsay C, Castanares Geocel-Grace, Rutter Amanda, Kyle Dennis E
Abstract excerpt
Artemisinin derivatives are used in combination with other antimalarial drugs for treatment of multidrug-resistant malaria worldwide. Clinical resistance to artemisinin recently emerged in southeast Asia, yet in vitro phenotypes for discerning mechanism(s) of resistance remain elusive. Here, we describe novel phenotypic resistance traits expressed by artemisinin-resistant Plasmodium falciparum. The resistant...
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