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Article

Multiple Phenotypic and Genotypic Artemisinin Sensitivity Evaluation of Malian Plasmodium falciparum Isolates.

The American journal of tropical medicine and hygiene - 1 Apr 2018

Niaré Karamoko, Paloque Lucie, Ménard Sandie, Tor Pety, Ramadani Arba P, Augereau Jean-Michel, Dara Antoine, Berry Antoine, Benoit-Vical Françoise, Doumbo Ogobara K

Abstract excerpt

We assessed the ex vivo/in vitro sensitivity of 54 Malian Plasmodium falciparum isolates to artemisinin for the monitoring of drug resistance in this area. The artemisinin sensitivity of parasites was evaluated using 1) the ex vivo and in vitro parasite recrudescence detection after treatment of the ring stage with 1-200 nM artemisinin for 48 hours and 2) the in vitro parasite recrudescence kinetics assay over 7...

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Identifiers

PMID: 29436338
DOI: 10.4269/ajtmh.17-0798
PMCID: PMC5928831

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