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Article

Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studies.

The Lancet. Infectious diseases - 1 Dec 2013

Witkowski Benoit, Amaratunga Chanaki, Khim Nimol, Sreng Sokunthea, Chim Pheaktra, Kim Saorin, Lim Pharath, Mao Sivanna, Sopha Chantha, Sam Baramey, Anderson Jennifer M, Duong Socheat, Chuor Char Meng, Taylor Walter R J, Suon Seila, Mercereau-Puijalon Odile, Fairhurst Rick M, Menard Didier

Abstract excerpt

BACKGROUND: Artemisinin resistance in Plasmodium falciparum lengthens parasite clearance half-life during artemisinin monotherapy or artemisinin-based combination therapy. Absence of in-vitro and ex-vivo correlates of artemisinin resistance hinders study of this phenotype. We aimed to assess whether an in-vitro ring-stage survival assay (RSA) can identify culture-adapted P falciparum isolates from patients with...

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Identifiers

PMID: 24035558
DOI: 10.1016/S1473-3099(13)70252-4
PMCID: PMC5015432

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