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Contribution of colibactin-producing Escherichia coli to colonic carcinogenesis

1 Apr 2025

Abstract excerpt

Familial adenomatous polyposis (FAP) is an autosomal dominant disorder characterised by multiple colorectal adenomas caused by a germline pathological variant of APC.1 The development of colorectal cancer (CRC) has interindividual differences. Recently, colibactin-producing E. coli (pks+E. coli) has attracted attention as a factor affecting CRC development. Currently, pks+E. coli is detected in 67% of patients...

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PMID: 40589427
DOI: 10.1136/egastro-2024-100177

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