Article
Receptor interacting protein-2 plays a critical role in human lung epithelial cells survival in response to Fas-induced cell-death.
PloS one - 1 Jan 2014
Rahman Mohd Akhlakur, Sundaram Kruthika, Mitra Srabani, Gavrilin Mikhail A, Wewers Mark D
Abstract excerpt
Lung epithelial cell death is critical to the lung injury that occurs in the acute respiratory distress syndrome. It is known that FasL plays a prominent role in this lung cell death pathway and may work in part through activation of the receptor interacting protein-2 (RIP2). RIP2 is serine/threonine kinase with a C-terminal caspase activation and recruitment domain (CARD). This CARD contains a highly conserved,...
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