Article
Potential Role of ASC, a Proapoptotic Protein, for Determining the Cisplatin Susceptibility of Lung Cancer Cells.
The Tohoku journal of experimental medicine - 1 Feb 2018
Sakaizawa Takao, Matsumura Tomio, Fujii Chifumi, Hida Shigeaki, Toishi Masayuki, Shiina Takayuki, Yoshida Kazuo, Hamanaka Kazutoshi, Ito Ken-Ichi, Taniguchi Shun'ichiro
Abstract excerpt
Primary lung cancer is the most frequent cause of cancer-related deaths worldwide. Cisplatin has been used as a key drug in the treatment for patients with lung cancer; however, most of the patients failed to respond to cisplatin within several months, and the mechanisms underlying the cisplatin resistance have not been fully elucidated. Apoptosis-associated speck-like protein containing a caspase recruitment...
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