Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spd2 assists Spd1 in the modulation of ribonucleotide reductase architecture but does not regulate deoxynucleotide pools.

Journal of cell science - 1 Jun 2014

Vejrup-Hansen Rasmus, Fleck Oliver, Landvad Katrine, Fahnøe Ulrik, Broendum Sebastian S, Schreurs Ann-Sofie, Kragelund Birthe B, Carr Antony M, Holmberg Christian, Nielsen Olaf

Abstract excerpt

In yeasts, small intrinsically disordered proteins (IDPs) modulate ribonucleotide reductase (RNR) activity to ensure an optimal supply of dNTPs for DNA synthesis. The Schizosaccharomyces pombe Spd1 protein can directly inhibit the large RNR subunit (R1), import the small subunit (R2) into the nucleus and induce an architectural change in the R1-R2 holocomplex. Here, we report the characterization of Spd2, a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Allosteric Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Cycle

Share to Checkpoint Kinase 2

Share to Intrinsically Disordered Proteins

Share to Ribonucleotide Reductases

Share to Schizosaccharomyces

Share to Schizosaccharomyces pombe Proteins

Source

Identifiers

PMID: 24652833
DOI: 10.1242/jcs.139816

Genes

ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spd2 assists Spd1 in the modulation of ribonucleotide reductase architecture but does not regulate deoxynucleotide pools.PMID 24652833Read ↗

Ribonucleotide reductase activity is coupled to DNA synthesis via proliferating cell nuclear antigen.Semantic proximity Read ↗

Ddb1 is required for the proteolysis of the Schizosaccharomyces pombe replication inhibitor Spd1 during S phase and after DNA damage.Semantic proximity Read ↗

DNA binding domain in the replication checkpoint protein Mrc1 of Schizosaccharomyces pombe.Semantic proximity Read ↗

Cdm1, the smallest subunit of DNA polymerase d in the fission yeast Schizosaccharomyces pombe, is non-essential for growth and division.Semantic proximity Read ↗

The role of novel genes rrp1(+) and rrp2(+) in the repair of DNA damage in Schizosaccharomyces pombe.Semantic proximity Read ↗

Structural and mechanistic insights into Dis3L2–mediated degradation of structured RNASemantic proximity Read ↗

Connecting mutations of the RNA polymerase II C-terminal domain to complex phenotypic changes using combined gene expression and network analyses.Semantic proximity Read ↗

Identification of RNR4, encoding a second essential small subunit of ribonucleotide reductase in Saccharomyces cerevisiae.Semantic proximity Read ↗

DRC1, DNA replication and checkpoint protein 1, functions with DPB11 to control DNA replication and the S-phase checkpoint in Saccharomyces cerevisiae.Semantic proximity Read ↗

The C-terminus of Dpb2 is required for interaction with Pol2 and for cell viability.Semantic proximity Read ↗

Characterisation of XlCdc1, a Xenopus homologue of the small (PolD2) subunit of DNA polymerase delta; identification of ten conserved regions I-X based on protein sequence comparisons across ten eukaryotic species.Semantic proximity Read ↗

Silencing motifs in the Clr2 protein from fission yeast, Schizosaccharomyces pombe.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.