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Article

Ribonucleotide reductase activity is coupled to DNA synthesis via proliferating cell nuclear antigen.

Current biology : CB - 24 Apr 2012

Salguero Israel, Guarino Estrella, Shepherd Marianne E A, Deegan Tom D, Havens Courtney G, MacNeill Stuart A, Walter Johannes C, Kearsey Stephen E

Abstract excerpt

Synthesis of deoxynucleoside triphosphates (dNTPs) is required for both DNA replication and DNA repair and is catalyzed by ribonucleotide reductases (RNR), which convert ribonucleotides to their deoxy forms [1, 2]. Maintaining the correct levels of dNTPs for DNA synthesis is important for minimiz...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22464192
DOI: 10.1016/j.cub.2012.02.070
PMCID: PMC4007158

Genes

PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22464192-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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