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Kidney fibrosis molecular mechanisms Spp1 influences fibroblast activity through transforming growth factor beta smad signaling

9 May 2024

Abstract excerpt

Kidney fibrosis marks a critical phase in chronic kidney disease with its molecular intricacies yet to be fully understood. This study's deep dive into single-cell sequencing data of renal tissue during fibrosis pinpoints the pivotal role of fibroblasts and myofibroblasts in the fibrotic transformation. Through identifying distinct cell populations and conducting transcriptomic analysis, Spp1 emerged as a key...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39323737
DOI: 10.1016/j.isci.2024.109839

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