Article
Ribosomes in a stacked array: elucidation of the step in translation elongation at which they are stalled during S-adenosyl-L-methionine-induced translation arrest of CGS1 mRNA.
The Journal of biological chemistry - 2 May 2014
Yamashita Yui, Kadokura Yoshitomo, Sotta Naoyuki, Fujiwara Toru, Takigawa Ichigaku, Satake Akiko, Onouchi Hitoshi, Naito Satoshi
Abstract excerpt
Expression of CGS1, which codes for an enzyme of methionine biosynthesis, is feedback-regulated by mRNA degradation in response to S-adenosyl-L-methionine (AdoMet). In vitro studies revealed that AdoMet induces translation arrest at Ser-94, upon which several ribosomes stack behind the arrested one, and mRNA degradation occurs at multiple sites that presumably correspond to individual ribosomes in a stacked...
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