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Article

The evolutionarily conserved eukaryotic arginine attenuator peptide regulates the movement of ribosomes that have translated it.

Molecular and cellular biology - 1 Dec 1998

Wang Z, Fang P, Sachs M S

Abstract excerpt

Translation of the upstream open reading frame (uORF) in the 5' leader segment of the Neurospora crassa arg-2 mRNA causes reduced initiation at a downstream start codon when arginine is plentiful. Previous examination of this translational attenuation mechanism using a primer-extension inhibition (toeprint) assay in a homologous N. crassa cell-free translation system showed that arginine causes ribosomes to stall...

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Identifiers

PMID: 9819438
DOI: 10.1128/MCB.18.12.7528
PMCID: PMC109333

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The evolutionarily conserved eukaryotic arginine attenuator peptide regulates the movement of ribosomes that have translated it.PMID 9819438Read ↗

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