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Betatrophin Versus Bitter-Trophin and the Elephant in the Room: Time for a New Normal in β-Cell Regeneration Research

13 Mar 2014

Abstract excerpt

The purpose of studying pancreatic β-cells in nonhuman species is to learn how to protect and regenerate the supply of residual endogenous β-cells in the face of the immunologic attack of type 1 diabetes, and the glucolipotoxic, inflammatory, endoplasmic reticulum- and oxidative stress–inducing environment of type 2 diabetes. β-Cell replication was unimaginable 20 years ago, when many believed that β-cells were...

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PMID: 24651805
DOI: 10.2337/db14-0009

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