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Article

Molecular Bases and Specificity behind the Activation of the Immune System OAS/RNAse L Pathway by Viral RNA.

Viruses - 2 Aug 2024

Jung-Rodriguez Emma, Barbault Florent, Bignon Emmanuelle, Monari Antonio

Abstract excerpt

The first line of defense against invading pathogens usually relies on innate immune systems. In this context, the recognition of exogenous RNA structures is primordial to fight, notably, against RNA viruses. One of the most efficient immune response pathways is based on the sensing of RNA double helical motifs by the oligoadenylate synthase (OAS) proteins, which in turn triggers the activity of RNase L and,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39205220
DOI: 10.3390/v16081246
PMCID: PMC11359028

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