Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A physiologically based model of orexinergic stabilization of sleep and wake.

PloS one - 1 Jan 2014

Fulcher Ben D, Phillips Andrew J K, Postnova Svetlana, Robinson Peter A

Abstract excerpt

The orexinergic neurons of the lateral hypothalamus (Orx) are essential for regulating sleep-wake dynamics, and their loss causes narcolepsy, a disorder characterized by severe instability of sleep and wake states. However, the mechanisms through which Orx stabilize sleep and wake are not well understood. In this work, an explanation of the stabilizing effects of Orx is presented using a quantitative model of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Stem
Share to Hypothalamus
Share to Intracellular Signaling Peptides and Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Narcolepsy

Share to Neuropeptides

Share to Orexins

Share to Wakefulness

Source

Open in PubMed Open full text

Identifiers

PMID: 24651580
DOI: 10.1371/journal.pone.0091982
PMCID: PMC3961294

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A physiologically based model of orexinergic stabilization of sleep and wake.PMID 24651580Read ↗

Circadian-Modulated Thresholds as a Mechanistic Basis for Sleep-Wake Transitions, Recovery, and SleepinessSemantic proximity Read ↗

Abnormal sleep/wake dynamics in orexin knockout mice.Semantic proximity Read ↗

Orexin neurons suppress narcolepsy via 2 distinct efferent pathways.Semantic proximity Read ↗

The How and Why of Sleep: Motor Theory and Catecholamine HypothesisSemantic proximity Read ↗

Different neuronal phenotypes in the lateral hypothalamus and their role in sleep and wakefulness.Semantic proximity Read ↗

Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation.Semantic proximity Read ↗

Control of sleep and wakefulness.Semantic proximity Read ↗

New developments in sleep research: molecular genetics, gene expression, and systems neurobiology.Semantic proximity Read ↗

Orexinergic neuron gene polymorphisms affect the sleep-wakefulness transition and hemodynamic stability during propofol, dexmedetomidine and remifentanil anesthesiaSemantic proximity Read ↗

Glutamatergic neurons in the preoptic hypothalamus promote wakefulness, destabilize NREM sleep, suppress REM sleep, and regulate cortical dynamicsSemantic proximity Read ↗

Dual Orexin and MCH neuron-ablated mice display severe sleep attacks and cataplexySemantic proximity Read ↗

Hypocretin (orexin) is critical in sustaining theta/gamma-rich waking behaviors that drive sleep need.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.