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Circadian-Modulated Thresholds as a Mechanistic Basis for Sleep-Wake Transitions, Recovery, and Sleepiness

2026-02-06

Abstract excerpt

Human sleep-wake cycles arise from the interplay between homeostatic sleep pressure and circadian rhythms, yet the underlying mechanistic basis by which these drives jointly govern state transitions, recovery from sleep loss, and subjective sleepiness remains unclear. Here, we use the extended Phillips-Robinson model incorporating circadian excitation of orexin and locus coeruleus populations, yielding analyticall...

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Literature Corpus work
d7fdd588-fe20-5c48-8dd9-0be4d681ccd8
DOI
10.64898/2026.02.04.703688
Open publication

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Circadian-Modulated Thresholds as a Mechanistic Basis for Sleep-Wake Transitions, Recovery, and SleepinessDOI 10.64898/2026.02.04.703688
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