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Article

HHEX Promotes Hepatic-Lineage Specification through the Negative Regulation of Eomesodermin

20 Mar 2014

Abstract excerpt

Human embryonic stem cells (hESCs) could provide a major window into human developmental biology, because the differentiation methods from hESCs mimic human embryogenesis. We previously reported that the overexpression of hematopoietically expressed homeobox (HHEX) in the hESC-derived definitive endoderm (DE) cells markedly promotes hepatic specification. However, it remains unclear how HHEX functions in this...

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PMID: 24651531
DOI: 10.1371/journal.pone.0090791

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