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Article

Influence of Stochastic Gene Expression on the Cell Survival Rheostat after Traumatic Brain Injury

11 Aug 2011

Abstract excerpt

Experimental evidence suggests that random, spontaneous (stochastic) fluctuations in gene expression have important biological consequences, including determination of cell fate and phenotypic variation within isogenic populations. We propose that fluctuations in gene expression represent a valuable tool to explore therapeutic strategies for patients who have suffered traumatic brain injury (TBI), for which there...

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PMID: 21853077
DOI: 10.1371/journal.pone.0023111

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