Article
Cells of NG2 lineage increase in glomeruli of mice following podocyte depletion.
American journal of physiology. Renal physiology - 1 Nov 2018
Suzuki Taihei, Eng Diana G, McClelland Aaron D, Pippin Jeffrey W, Shankland Stuart J
Abstract excerpt
Under certain circumstances, podocytes can be partially replaced following their loss in disease. The inability of podocytes to proliferate suggests that replacement derives from other cell types. Because neural/glial antigen 2 (NG2)-expressing cells can serve as progenitors in other organs and because herein we showed increased NG2 staining in podocytes following their loss in experimental focal segmental...
Topics
- A Kinase Anchor Proteins
- Animals
- Antigens
- Biomarkers
- Cell Cycle Proteins
- Cell Lineage
- Cell Proliferation
- Cell Transdifferentiation
- Disease Models, Animal
- Glomerulosclerosis, Focal Segmental
- Integrin alpha Chains
- Kidney Glomerulus
- Mice