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Article

Parietal epithelial cell differentiation to a podocyte fate in the aged mouse kidney

28 Aug 2020

Abstract excerpt

mice were generated. PECs were inducibly labeled with a tdTomato reporter, and podocytes were constitutively labeled with an EGFP reporter. With advancing age (14 and 24 months) glomeruli in the juxta-medullary cortex (JMC) were more severely injured than those in the outer cortex (OC). In aged mice (24m), injured glomeruli with lower podocyte number (41% decrease), showed more PEC migration and differentiation...

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Identifiers

PMID: 32858527
DOI: 10.18632/aging.103788

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