Article
Evidence for population-specific positive selection on immune genes of Anopheles gambiae.
G3 (Bethesda, Md.) - 1 Dec 2012
Crawford Jacob E, Bischoff Emmanuel, Garnier Thierry, Gneme Awa, Eiglmeier Karin, Holm Inge, Riehle Michelle M, Guelbeogo Wamdaogo M, Sagnon N'Fale, Lazzaro Brian P, Vernick Kenneth D
Abstract excerpt
Host-pathogen interactions can be powerful drivers of adaptive evolution, shaping the patterns of molecular variation at the genes involved. In this study, we sequenced alleles from 28 immune-related loci in wild samples of multiple genetic subpopulations of the African malaria mosquito Anopheles gambiae, obtaining unprecedented sample sizes and providing the first opportunity to contrast patterns of molecular...
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