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The serine protease inhibitor serpinB2 binds and stabilizes p21 in senescent cells

10 Aug 2017

Abstract excerpt

SerpinB2 is a serine protease inhibitor also known as plasminogen activator inhibitor type 2 (PAI-2). It has been well documented that serpinB2 is an inhibitor of urokinase plasminogen activator (uPA) and tissue plasminogen activator (tPA). Interestingly, serpinB2 levels are increased in senescent cells and serpinB2 is thus considered a senescence biomarker. In this study, by mimicking the elevated levels of...

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PMID: 28794016
DOI: 10.1242/jcs.204974

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